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Nevertheless, one should keep in mind that small changes in DNA methylation (situated on only one or a few not densely packed CGs) might not be detected by genome-wide DNA methylation profiling methods, such as the methyl-cytosine immunoprecipitation and reduced-representation bisulfite sequencing used in the above-mentioned studies (Fouse et al., 2008

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It does not establish a validated human dose, half-life, or dosing schedule for either compound